From version 3.45 we have made a change to the Autotask configuration. To prevent issues, please check out our latest announcements for more information.
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Removal: Autotask Instance ConnectionString after release V3.33

Hi, 

The Autotask Instance ConnectionString will be removed after release V3.33.

We have seen that this is not being used on instance level. This means, after release V3.33, it's only possible to configure Autotask on environment level.