From version 3.45 we have made a change to the Autotask configuration. To prevent issues, please check out our latest announcements for more information.
Hi ,
Welcome to the Support Portal. How can we help?

Is it possible to create a completely unique URL for a Workspace 365 environment?

This is possible for parties which host Workspace 365 themselves (server-wise). Contact your specific reseller to discuss if this is possible. If we (New Day at Work B.V. - Workspace 365) are hosting your Workspace, this is also possible. 

Make sure you have a valid certificate (.pfx) for the URL you want to bind to the Workspace. Contact  for more information.